Miller M T, Strömland K
Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine.
Trans Am Ophthalmol Soc. 1992;90:247-60; discussion 260-3.
Our study of individuals with thalidomide embryopathy reaffirms many of the principles of clinical teratology concerning sensitivity of developing structures and specificity of action. It also highlights important features of ocular teratology that differ from those of other organ systems. Because malformations of the eye and associated structures do not significantly threaten the survival of the embryo, fetus, or neonate, any variation in prevalence in older individuals is not due to the nature of the ocular malformation but may be significantly modified by "the company they keep," the systemic malformations occurring at the same time as the original insult, whether it be an environmental, a genetic, or a local disturbance. Additionally, the presence of clusters of malformations caused by a teratogen at a specific time supports the concept of a common pathogenic mechanism and provides suggested avenues for further research into the cause of these malformations.
我们对沙利度胺胚胎病个体的研究再次证实了临床致畸学的许多原则，这些原则涉及发育结构的敏感性和作用的特异性。它还突出了眼致畸学与其他器官系统不同的重要特征。由于眼睛及相关结构的畸形不会显著威胁胚胎、胎儿或新生儿的存活，老年个体中患病率的任何变化并非源于眼部畸形的性质，而是可能会因“相伴的情况”而显著改变，即与最初损伤同时出现的全身畸形，无论这种损伤是环境因素、遗传因素还是局部干扰。此外，特定时间由致畸剂引起的畸形簇的存在支持了共同致病机制的概念，并为进一步研究这些畸形的病因提供了建议途径。
