Miller M T, Strömland K
Department of Ophthalmology, University of Illinois, Chicago Eye and Ear Infirmary 60612.
J Pediatr Ophthalmol Strabismus. 1991 Jan-Feb;28(1):47-54.
Twenty-one individuals, aged 28 to 29 years, with documented thalidomide embryopathy were examined in Sweden. The most noteworthy ophthalmologic finding was the high prevalence of incomitant horizontal strabismus, primarily of the Duane syndrome type. Less frequently seen were cases of both marked abduction and adduction limitation similar to a gaze paresis with no observable fissure changes, as well as a few cases of isolated abduction weakness or inferior oblique under-action. There were many examples of aberrant lacrimation, facial nerve palsy, and ear anomalies combined with horizontal incomitant forms of strabismus. Ear and facial nerve palsies are known to occur with ingestion of thalidomide early in the sensitive period (approximately days 21 to 26 after conception).
在瑞典，对21名年龄在28至29岁、有文献记录的沙利度胺胚胎病患者进行了检查。最值得注意的眼科发现是不共转性水平斜视的高患病率，主要为杜安综合征类型。较少见的情况是，既有明显的外展和内收受限，类似于无明显睑裂变化的凝视麻痹，也有少数孤立性外展无力或下斜肌功能不足的病例。有许多异常流泪、面神经麻痹和耳部异常合并水平不共转性斜视的例子。已知在敏感期早期（大约在受孕后21至26天）摄入沙利度胺会出现耳部和面神经麻痹。
