Flåøyen A, Smith B L
Department of Large Animal Clinical Sciences, Norwegian College of Veterinary Medicine, Oslo.
Vet Res Commun. 1992;16(5):337-44. doi: 10.1007/BF01839183.
The hepatic changes were compared in lambs photosensitized or not photosensitized after exposure to sporidesmin. Injury to both the parenchyma and the biliary system was more severe in the photosensitized than in the non-photosensitized lambs. The activities of gamma-glutamyltransferase and glutamate dehydrogenase, and the total, conjugated and unconjugated bilirubin concentrations were significantly higher in sera from the photosensitized than from the non-photosensitized lambs. Hepatic glycogen levels were decreased in both the photosensitized and the non-photosensitized lambs, but were significantly lower in the former. Hence it is possible that lesions in hepatocytes contribute to retention of phylloerythrin and so to photosensitization.
比较了暴露于柄曲霉素后光敏和未光敏羔羊的肝脏变化。光敏羔羊的实质和胆道系统损伤比未光敏羔羊更严重。光敏羔羊血清中的γ-谷氨酰转移酶和谷氨酸脱氢酶活性以及总胆红素、结合胆红素和未结合胆红素浓度显著高于未光敏羔羊。光敏和未光敏羔羊的肝糖原水平均降低，但前者显著更低。因此，肝细胞损伤可能导致叶红素潴留，进而导致光敏反应。
