Kyvik K R, Brattebø G, Tysnes O B, Oyen N, Sandberg S, Riise T, Holmsen H, Aarli J A
Department of Neurology, University of Bergen, Norway.
J Occup Med. 1992 Jul;34(7):687-92.
Organic solvents probably exert their clinical effects through distortion of cellular membrane structure and function. Blood platelets represent an easily available membrane system. This study describes an evaluation of mean platelet volume (MPV) and total platelet count (TPC) in a group of workers exposed to a mixture of organic solvents in paint factories. We have found a correlation between decreased MPV and present exposure. The reduction was reversed within an exposure-free interval of 3 weeks. The intracellular adenosine triphosphate/adenosine diphosphate (ATP/ADP) ratio was significantly increased in exposed workers, compatible with dense granule secretion. A quantitative study of the phosphoinositide cycle in the platelets revealed an increased concentration of the phosphatidic acid, indicating an increased turnover. These findings are consistent with a solvent-induced activation of circulating platelets.
有机溶剂可能通过扭曲细胞膜结构和功能来发挥其临床作用。血小板代表一种易于获取的膜系统。本研究描述了对油漆厂中一组接触有机溶剂混合物的工人的平均血小板体积（MPV）和血小板总数（TPC）的评估。我们发现MPV降低与当前接触有关。在3周的无接触期内，这种降低得到了逆转。接触有机溶剂的工人细胞内三磷酸腺苷/二磷酸腺苷（ATP/ADP）比值显著升高，这与致密颗粒分泌相符。对血小板中磷酸肌醇循环的定量研究显示磷脂酸浓度增加，表明周转率增加。这些发现与溶剂诱导的循环血小板激活一致。
