Kuthiala A, Gupta R K, Davis E E
Letterman Army Institute of Research, Presidio San Francisco, Calif. 94129.
J Med Entomol. 1992 Jul;29(4):639-43. doi: 10.1093/jmedent/29.4.639.
The insect repellent, N,N-diethyl-m-toluamide (deet), interferes with detection of the host attractant, lactic acid (LA), by LA-excited neurons on the antennae of female Aedes aegypti (L.) mosquitoes. In the current laboratory behavioral experiment, the attraction of gravid female mosquitoes to a source of ethyl propionate, an oviposition attractant, was reduced by a factor of two when deet was present. Similarly, when deet was presented together with ethyl propionate in electrophysiological experiments, sensitivity of the neural response to ethyl propionate was depressed in a transient, dose-dependent manner that could account for the reduction in behavioral attraction of gravid females to ethyl propionate. Electrophysiologically, the sensitivity of oviposition attractant receptors to ethyl propionate on gravid females was not different from that on nongravid host-seeking females. The similarity between the depression of sensitivity of the oviposition attractant-sensitive neurons induced by deet and that observed in the host attractant-sensitive neurons suggest a common mode of action of deet on peripheral chemoreceptor neurons that mediate these behaviors.
驱蚊剂N,N - 二乙基 - 间甲苯甲酰胺（避蚊胺）会干扰埃及伊蚊雌蚊触角上对宿主引诱剂乳酸（LA）产生兴奋反应的神经元对宿主引诱剂乳酸的检测。在当前的实验室行为实验中，当存在避蚊胺时，孕蚊对产卵引诱剂丙酸乙酯源的吸引力降低了一半。同样，在电生理实验中，当避蚊胺与丙酸乙酯同时出现时，神经对丙酸乙酯反应的敏感性以一种短暂的、剂量依赖性的方式受到抑制，这可以解释孕蚊对丙酸乙酯行为吸引力的降低。在电生理方面，孕蚊产卵引诱剂受体对丙酸乙酯的敏感性与未孕的寻找宿主雌蚊的敏感性没有差异。避蚊胺诱导的产卵引诱剂敏感神经元敏感性降低与宿主引诱剂敏感神经元中观察到的情况相似，这表明避蚊胺对外周化学感受器神经元介导这些行为存在共同的作用模式。
