Okuda Y, Kitajima T, Ogata H
First Department of Anesthesiology, Dokkyo University School of Medicine, Tochigi.
Masui. 1992 Jul;41(7):1076-81.
Ten mongrel dogs were divided into two groups; stellate ganglion block (SGB, n = 5) group and stellate ganglion resection (SGR, n = 5) group. Anesthesia was induced with pentobarbital 25 mg.kg-1. The animals were mechanically ventilated to maintain a constant PaCO2 (35-40 mmHg). Left common carotid arterial flow (CCAF), left external carotid arterial flow (ECAF), left vertebral arterial flow (VAF) and left brachial arterial flow (BAF) were measured using an ultrasonic transit time flowmeter. Internal carotid arterial flow (ICAF) was calculated by subtracting ECAF from CCAF. After thoracotomy, the first SGB with 0.5% mepivacaine 1.5 ml or SGR was performed. Ninety minutes after the first SGB, the second SGB was performed. The data were taken for 180 minutes after the first SGB or SGR. In SGB, CCAF and BAF increased significantly for the duration of action of local anesthetic. But VAF and ICAF increased significantly for a short time after the block. In SGR, CCAF, BAF and ICAF increased significantly during the experiment. But VAF showed a transitory increase immediately after the resection. The authors conclude that sympathetic ganglion block with local anesthetic should be performed repeatedly when increase of blood flow in blood vessels with strong autoregulation from the brain is anticipated.
将10只杂种犬分为两组:星状神经节阻滞(SGB,n = 5)组和星状神经节切除术(SGR,n = 5)组。用25mg.kg-1的戊巴比妥诱导麻醉。动物进行机械通气以维持恒定的PaCO2(35 - 40mmHg)。使用超声渡越时间流量计测量左颈总动脉血流(CCAF)、左颈外动脉血流(ECAF)、左椎动脉血流(VAF)和左肱动脉血流(BAF)。颈内动脉血流(ICAF)通过从CCAF中减去ECAF来计算。开胸后,进行第一次0.5%甲哌卡因1.5ml的SGB或SGR。第一次SGB后90分钟,进行第二次SGB。在第一次SGB或SGR后180分钟采集数据。在SGB中,在局部麻醉药作用期间CCAF和BAF显著增加。但VAF和ICAF在阻滞后短时间内显著增加。在SGR中,实验期间CCAF、BAF和ICAF显著增加。但VAF在切除后立即出现短暂增加。作者得出结论,当预期来自大脑的具有强大自身调节功能的血管血流增加时,应反复进行局部麻醉药交感神经节阻滞。