家族性多发性硬化症中的人类白细胞抗原决定簇

HLA determinants in familial multiple sclerosis.

作者信息

Grasso M G, Cutrupi F, Bernardi S, Trabace S, Pozzilli C, Cappellacci S, Fieschi C

机构信息

Department of Neurological Sciences, University of Rome, Italy.

出版信息

Neuroepidemiology. 1992;11(2):85-9. doi: 10.1159/000110916.

DOI:10.1159/000110916

PMID:1495578

Abstract

HLA-A, -B, -C, -DR, -DQ antigens were studied in 11 multiplex MS families, 11 single-case MS families and 100 healthy subjects. The HLA DR4 was the most frequent antigen in all MS patients (p = 0.015). When the antigenic frequency in index familial cases was compared with that in single cases, the DR4 antigen was found to be more frequent (p = 0.01) in familial cases only. Furthermore, when the DR4 antigen was excluded from the analysis, we observed an increase in DR2 (p = 0.11) only in the familial MS cases. These results can be compatible with a multifactorial hypothesis according to which the HLA genes have an important role in MS susceptibility in familial cases.

摘要

对11个多发性硬化症（MS）家系、11个单发病例的MS家系以及100名健康受试者进行了人类白细胞抗原（HLA）-A、-B、-C、-DR、-DQ抗原研究。HLA DR4是所有MS患者中最常见的抗原（p = 0.015）。当将索引家族病例中的抗原频率与单发病例中的抗原频率进行比较时，发现DR4抗原仅在家族病例中更常见（p = 0.01）。此外，当在分析中排除DR4抗原时，我们仅在家族性MS病例中观察到DR2增加（p = 0.11）。这些结果可能与多因素假说相符，根据该假说，HLA基因在家族性病例的MS易感性中起重要作用。