威尔士东南部的人类白细胞抗原与多发性硬化症
HLA and multiple sclerosis in south east Wales.
作者信息
Swingler R J, Kirk P F, Darke C, Compston D A
机构信息
Department of Neurology, University of Wales College of Medicine, Cardiff, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1987 Sep;50(9):1153-5. doi: 10.1136/jnnp.50.9.1153.
Abstract
A stronger association has been found between multiple sclerosis and HLA-DR2 than -DQwl in south east Wales (prevalence c 113/10(5)) in contrast to recent observations in north east Scotland (prevalence 178/10(5). The complex relationship between the HLA system and multiple sclerosis, demonstrated in this and other studies, is explained more easily under a polygenic model of inheritance, in which environmental events and genes interact, than by the presence of a single susceptibility gene.
摘要
在威尔士东南部（患病率约为113/10⁵），已发现多发性硬化症与HLA - DR2之间的关联比与HLA - DQw1的关联更强，这与苏格兰东北部最近的观察结果（患病率178/10⁵）形成对比。在本研究及其他研究中所证明的HLA系统与多发性硬化症之间的复杂关系，在多基因遗传模型（环境因素与基因相互作用）下比在单一易感基因存在的情况下更容易解释。
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本文引用的文献
1
The chief scientist reports ... multiple sclerosis in North East Scotland.
Health Bull (Edinb). 1984 May;42(3):151-6.
2
HLA-linked and unlinked determinants of multiple sclerosis.多发性硬化症的HLA连锁和非连锁决定因素。
Immunogenetics. 1982;15(5):509-17. doi: 10.1007/BF00345910.
3
The distribution of multiple sclerosis in the United Kingdom.英国多发性硬化症的分布情况。
J Neurol Neurosurg Psychiatry. 1986 Oct;49(10):1115-24. doi: 10.1136/jnnp.49.10.1115.
4
Multiple sclerosis and HLA DQw1.多发性硬化症与HLA DQw1
Lancet. 1986 Jan 25;1(8474):211. doi: 10.1016/s0140-6736(86)90684-7.
5
Association between HLA-D region epitopes and multiple sclerosis in Arabs.
Tissue Antigens. 1986 Apr;27(4):196-200. doi: 10.1111/j.1399-0039.1986.tb01520.x.
6
A single mutation hypothesis for multiple sclerosis based on the HL-A system.基于人类白细胞抗原（HL-A）系统的多发性硬化单一突变假说。
Neurology. 1976 Jun;26(6 PT 2):56-8. doi: 10.1212/wnl.26.6_part_2.56.
7
Genetic analysis of multiple sclerosis in Orkney.奥克尼群岛多发性硬化症的基因分析。
J Epidemiol Community Health. 1979 Dec;33(4):229-35. doi: 10.1136/jech.33.4.229.
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