Stagnaro-Green A
Department of Medicine, Mount Sinai School of Medicine, New York, New York.
Obstet Gynecol. 1992 Sep;80(3 Pt 2):490-2.
Thyroid dysfunction is a common postpartum event affecting as many as 16.7% of women. The purpose of this paper was to report the first known case of post-miscarriage thyroid dysfunction.
A 32-year-old woman with a 9-year history of infertility underwent in vitro fertilization. After two spontaneous miscarriages, she delivered a full-term healthy child. Spontaneous menses did not return following delivery, and hormonal evaluation revealed severe postpartum thyroid disease associated with hyperprolactinemia. Retrospective analysis of frozen sera revealed thyroid dysfunction and hyperprolactinemia after the first miscarriage, even though the gestation lasted only 47 days.
The present case of thyroid dysfunction following a first-trimester miscarriage raises issues concerning the immunology of pregnancy and thyroid dysfunction after pregnancy. The incidence of post-miscarriage thyroid dysfunction and severe postpartum thyroid disease resulting in amenorrhea requires further study.
甲状腺功能障碍是一种常见的产后疾病，影响多达16.7%的女性。本文的目的是报告首例已知的流产后甲状腺功能障碍病例。
一名有9年不孕史的32岁女性接受了体外受精。两次自然流产后，她生下了一个足月健康的婴儿。产后月经未复潮，激素评估显示严重的产后甲状腺疾病伴高催乳素血症。对冷冻血清的回顾性分析显示，第一次流产后即出现甲状腺功能障碍和高催乳素血症，尽管妊娠仅持续了47天。
本例孕早期流产后出现甲状腺功能障碍，引发了关于妊娠免疫学及妊娠后甲状腺功能障碍的问题。流产后甲状腺功能障碍以及导致闭经的严重产后甲状腺疾病的发生率有待进一步研究。
