Pop V J, de Rooy H A, Vader H L, van der Heide D, Essed G G, de Geus C A
St. Joseph Ziekenhuis, Veldhoven.
Ned Tijdschr Geneeskd. 1992 May 9;136(19):917-21.
In a longitudinal study the incidence of postpartum thyroid dysfunction in the Netherlands was investigated in an unselected open population. There were 293 women who were screened by repeated assessments of thyroid function until 34 weeks postpartum at 6-week intervals. Thyroid dysfunction was defined as abnormal TSH values accompanied by abnormal FT4 and (or) FT3 values. The frequency of postpartum thyroid dysfunction was 7.2% (n = 21). Most of the thyroid dysfunction occurred between 16 and 28 weeks postpartum. There were five women with subclinical thyroid dysfunction: abnormal TSH values with complementary FT4 and (or) FT3 changes within normal limits. Four of them showed (marked) increase in antimicrosomal antibody titres. With the inclusion of the five women the frequency rose to 8.9%. These data appear representative for the Netherlands as a whole, suggesting that every year 14,000 women suffer from (transient) postpartum thyroid dysfunction.
在一项纵向研究中，对荷兰一个未经过筛选的开放人群的产后甲状腺功能障碍发病率进行了调查。共有293名女性参与研究，通过每隔6周重复评估甲状腺功能，直至产后34周。甲状腺功能障碍定义为促甲状腺激素（TSH）值异常并伴有游离甲状腺素（FT4）和（或）游离三碘甲状腺原氨酸（FT3）值异常。产后甲状腺功能障碍的发生率为7.2%（n = 21）。大多数甲状腺功能障碍发生在产后16至28周之间。有5名女性患有亚临床甲状腺功能障碍：TSH值异常，同时游离甲状腺素和（或）游离三碘甲状腺原氨酸变化在正常范围内。其中4名女性抗微粒体抗体滴度（显著）升高。将这5名女性纳入后，发生率升至8.9%。这些数据似乎代表了整个荷兰的情况，表明每年有14,000名女性患有（暂时性）产后甲状腺功能障碍。
