Catarci T, Clifford Rose F
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome, Italy.
Pathol Biol (Paris). 1992 Apr;40(4):284-6.
Since the time of Liveing and Gowers in the nineteenth century, migraine has been thought to be inherited, although family history has been widely studied, nearly all the reports are not scientifically based and studies on twins have never shown 100% concordance in monozygotic (MZ) pairs, indicating that migraine cannot be inherited by a single gene. Furthermore, the criteria for a polygenic trait are not fulfilled by migraine patients. The only two syndromes with a strong genetic basis of inheritance are familial hemiplegic migraine and migraine occurring in Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes (MELAS). It is the predisposition to headache that is likely to be inherited; this is supported by the induction of migraine-like headaches with either m-chlorophenyl-piperazine (m-CPP) or nitroglycerin in normal subjects with a positive family history for migraine.
自19世纪利文和高尔斯时代以来，偏头痛就被认为具有遗传性，尽管家族病史已得到广泛研究，但几乎所有报告都缺乏科学依据，对双胞胎的研究从未显示同卵双胞胎（MZ）的一致性达到100%，这表明偏头痛不能由单个基因遗传。此外，偏头痛患者也不符合多基因性状的标准。仅有的两种具有强大遗传基础的综合征是家族性偏瘫性偏头痛和伴乳酸性酸中毒和类卒中发作的线粒体脑肌病（MELAS）中的偏头痛。可能遗传的是头痛易感性；有偏头痛家族史阳性的正常受试者使用间氯苯哌嗪（m-CPP）或硝酸甘油诱发偏头痛样头痛，这一现象支持了这一点。
