Gaist D, Pedersen L, Madsen C, Tsiropoulos I, Bak S, Sindrup S, McGue M, Rasmussen B Krogh, Christensen K
Danish Twin Register & Epidemiology, Institute of Public Health, University of Southern Denmark.
Neurology. 2005 Feb 22;64(4):600-7. doi: 10.1212/01.WNL.0000151858.15482.66.
To investigate the cognitive functioning of migraineurs vs nonmigraineurs in a large population-based sample of middle-aged twins where headache diagnoses were established by neurologists.
Twins identified through the population-based Danish Twin Registry participated in face-to-face structured interviews, which included cognitive tests and two previously validated questions screening for migraine. Twins who screened positive for migraine and their co-twins were invited to participate in a telephone-based interview conducted by neurologists, who established headache diagnoses according to the International Headache Society criteria. Cognitive scores on fluency, digit span, delayed word recall, and symbol digit substitution test were compared between migraineurs and nonmigraineurs. Comparisons within monozygotic and dizygotic same sex twin pairs discordant for migraine were also performed.
Of the 1,789 twins who were eligible for inclusion in the present study, 1,393 (77.8%) were interviewed. A diagnosis of migraine was established in 536 twins (migraine without aura n = 347; migraine with aura n = 157). Average scores on cognitive tests in twins with migraine or one of the migraine subtypes did not differ from those of nonmigraineurs in any of the tests. Comparisons within twin pairs discordant for migraine produced highly comparable results. Adjustment for possible confounders and stratification by cumulated number of lifetime attacks did not influence the results.
A lifetime diagnosis of migraine was not associated with cognitive deficits in middle-aged subjects.
在一个基于人群的中年双胞胎大样本中，调查偏头痛患者与非偏头痛患者的认知功能，其中头痛诊断由神经科医生确定。
通过基于人群的丹麦双胞胎登记处识别出的双胞胎参加了面对面的结构化访谈，其中包括认知测试和两个先前经过验证的偏头痛筛查问题。偏头痛筛查呈阳性的双胞胎及其同卵双胞胎被邀请参加由神经科医生进行的电话访谈，神经科医生根据国际头痛协会标准确定头痛诊断。比较偏头痛患者和非偏头痛患者在流畅性、数字广度、延迟单词回忆和符号数字替换测试方面的认知得分。还对同卵和异卵同性双胞胎对中偏头痛不一致的情况进行了比较。
在本研究符合纳入条件的1789对双胞胎中，1393对（77.8%）接受了访谈。536对双胞胎被诊断为偏头痛（无先兆偏头痛n = 347；有先兆偏头痛n = 157）。患有偏头痛或偏头痛亚型之一的双胞胎在任何认知测试中的平均得分与非偏头痛患者没有差异。对偏头痛不一致的双胞胎对进行比较产生了高度可比的结果。对可能的混杂因素进行调整并按终生发作累积次数分层并未影响结果。
终生偏头痛诊断与中年受试者的认知缺陷无关。
