Pradalier A, Vincent D
Service de Médecine Interne, Hôpital Rothschild, Paris, France.
Pathol Biol (Paris). 1992 Apr;40(4):397-405.
Controlled studies of nonsteroidal antiinflammatory drugs (NSAIDs) for the management of migraine attacks or for the prophylactic long-term treatment of migraine are reviewed herein. A large number of NSAIDs have been tested against a placebo or reference drug, including aspirin, indomethacin, mefenamic acid, tolfenamic acid, flufenamic acid, ibuprofen, flurbiprofen, fenoprofen, naproxen and sodium naproxen, diclofenac and lornoxicam. For the treatment of acute attacks, published studies found that the NSAIDs were significantly more effective than the placebo and at least as effective as the reference drugs. Adverse effects were absent or mild in this indication. Studies of NSAIDs as prophylactic treatment of migraine attacks are less numerous but also point to the value of this approach. However, long-term use of NSAIDs is associated with side-effects, mainly involving the gastrointestinal tract.
本文综述了非甾体抗炎药（NSAIDs）用于偏头痛发作治疗或偏头痛长期预防性治疗的对照研究。大量NSAIDs已与安慰剂或参比药物进行了对比测试，包括阿司匹林、吲哚美辛、甲芬那酸、托芬那酸、氟芬那酸、布洛芬、氟比洛芬、非诺洛芬、萘普生和萘普生钠、双氯芬酸和氯诺昔康。对于急性发作的治疗，已发表的研究发现，NSAIDs比安慰剂显著更有效，且至少与参比药物一样有效。在此适应证中，不良反应不存在或很轻微。NSAIDs作为偏头痛发作预防性治疗的研究较少，但也表明了这种方法的价值。然而，NSAIDs的长期使用与副作用相关，主要涉及胃肠道。
