Pincus T, Swearingen C, Cummins P, Callahan L F
Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
J Rheumatol. 2000 Apr;27(4):1020-7.
To analyze results of treatment of osteoarthritis (OA) with acetaminophen and the nonsteroidal antiinflammatory drugs (NSAID) through a patient survey.
A 15 minute telephone survey was conducted with 300 patients, including 172 with confirmed OA.
Twenty-four percent of patients who took acetaminophen rated it as "very helpful," compared to 31% for ibuprofen, 30% for naproxen, and 56% for diclofenac. Drug continuation beyond 24 months was reported by 33% of patients for acetaminophen, 21% for ibuprofen, 17% for naproxen, and 19% for diclofenac. Acetaminophen was significantly less likely to be discontinued because of toxicity than NSAID. Patients who indicated that they would not take a drug again, and therefore be unlikely to participate in a clinical trial involving this drug, were 26% for acetaminophen, 40% for ibuprofen, 38% for naproxen, and 28% for diclofenac. About 30% of patients who took acetaminophen reported concurrent use of ibuprofen, naproxen, or diclofenac. Among the 67% of patients who identified a drug as "most helpful," 80% named an NSAID, compared to 20% who named acetaminophen or another analgesic as the "most helpful" drug.
Patients take many different drugs for OA, most of which are not continued beyond 2 years. Many patients take both acetaminophen and an NSAID. Most patients who identified a drug as "most helpful" named an NSAID rather than acetaminophen or an analgesic drug. These findings may be of value in further development of management strategies and guidelines for OA.
通过患者调查分析对乙酰氨基酚和非甾体抗炎药（NSAID）治疗骨关节炎（OA）的效果。
对300名患者进行了15分钟的电话调查，其中172名确诊为OA。
服用对乙酰氨基酚的患者中有24%将其评为“非常有效”，布洛芬为31%，萘普生为30%，双氯芬酸为56%。33%服用对乙酰氨基酚的患者报告用药持续超过24个月，布洛芬为21%，萘普生为17%，双氯芬酸为19%。与NSAID相比，对乙酰氨基酚因毒性而停药的可能性显著更低。表示不会再次服用某种药物，因此不太可能参与涉及该药物的临床试验的患者，服用对乙酰氨基酚的为26%，布洛芬为40%，萘普生为38%，双氯芬酸为28%。约30%服用对乙酰氨基酚的患者报告同时使用了布洛芬、萘普生或双氯芬酸。在67%认为某种药物“最有效”的患者中，80%提到了一种NSAID，相比之下，20%将对乙酰氨基酚或另一种镇痛药列为“最有效”药物。
患者针对OA服用多种不同药物，其中大多数用药时间不超过2年。许多患者同时服用对乙酰氨基酚和一种NSAID。大多数认为某种药物“最有效 ”的患者提到的是NSAID，而非对乙酰氨基酚或镇痛药。这些发现可能对OA管理策略和指南的进一步制定具有价值。
