Sherrill D, Sears M R, Lebowitz M D, Holdaway M D, Hewitt C J, Flannery E M, Herbison G P, Silva P A
Division of Respiratory Sciences, University of Arizona College of Medicine, Tucson 85724.
Pediatr Pulmonol. 1992 Jun;13(2):78-85. doi: 10.1002/ppul.1950130204.
We examined growth of spirometric lung function in 696 children of European ancestry who were followed from ages 9 to 15 years and stratified according to their degree of responsiveness to methacholine inhalation challenge, atopic status, and respiratory symptoms. Subjects were participants in the longitudinal Multidisciplinary Health and Development Study in Dunedin, New Zealand. Forced expired volume in 1 second (FEV1), and vital capacity (VC) were measured at 9, 11, 13, and 15 years of age, concurrently with assessment of airway responsiveness determined by the concentration of methacholine causing a 20% fall in FEV1 (PC20 FEV1). Atopic status was assessed at age 13 by skin-prick testing to 11 allergens. In children demonstrating airway hyperresponsiveness, FEV1 increased with age at a slower rate, and the FEV1/VC ratio had a faster rate of decline through childhood, compared to non-responsive children. Subjects with positive skin tests to house dust mite and cat dander also had lower mean FEV1/VC ratios than the control group. Any reported wheezing was associated with slower growth of FEV1 and VC in males. We conclude that in New Zealand children with airway responsiveness and/or atopy to house dust mite or cat growth of spirometric lung function is impaired.
我们对696名欧洲裔儿童的肺功能肺活量增长情况进行了研究，这些儿童从9岁到15岁接受跟踪观察，并根据他们对乙酰甲胆碱吸入激发试验的反应程度、特应性状态和呼吸道症状进行分层。研究对象参与了新西兰达尼丁的多学科纵向健康与发展研究。在9岁、11岁、13岁和15岁时测量1秒用力呼气量（FEV1）和肺活量（VC），同时通过导致FEV1下降20%的乙酰甲胆碱浓度（PC20 FEV1）评估气道反应性。13岁时通过对11种变应原进行皮肤点刺试验评估特应性状态。与无反应性儿童相比，表现出气道高反应性的儿童中，FEV1随年龄增长的速度较慢，且FEV1/VC比值在儿童期下降速度更快。对屋尘螨和猫皮屑皮肤试验呈阳性的受试者，其平均FEV1/VC比值也低于对照组。任何报告的喘息都与男性FEV1和VC的增长较慢有关。我们得出结论，在新西兰，具有气道反应性和/或对屋尘螨或猫皮屑特应性的儿童，其肺功能肺活量的增长受到损害。
