Kirsten D, Rieger U, Amthor M, Magnussen H
Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, LVA Freie und Hansestadt Hamburg.
Pneumologie. 1992 Jun;46(6):239-42.
Pulmonary sarcoidosis is a granulomatous disorder of unknown origin with a favorable outcome in most patients. However in about 5-10% progressive fibrosis is observed and may lead to further complications. We report on a 49 year-old woman with sarcoidosis with fibrotic changes and cavities in both upper lobes, who developed an upper lobe infiltration resistant to antibiotic treatment. Histologic examination of bronchial biopsy specimen revealed invasive aspergillosis. Therapy with Amphotericin B and Flucytosin was followed by marked clinical and radiological improvement.
肺结节病是一种病因不明的肉芽肿性疾病，大多数患者预后良好。然而，约5%-10%的患者会出现进行性纤维化，并可能导致进一步的并发症。我们报告了一名49岁患有结节病的女性，其双上叶出现纤维化改变和空洞，并且出现了对抗生素治疗耐药的上叶浸润。支气管活检标本的组织学检查显示为侵袭性曲霉菌病。使用两性霉素B和氟胞嘧啶治疗后，临床和影像学表现均有明显改善。
