Herishanu Yair, Trestman Svetlana, Kirgner Ilya, Rachmani Rodica, Naparstek Ella
Department of Hematology, Tel-Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, Israel.
Leuk Lymphoma. 2003 Dec;44(12):2103-8. doi: 10.1080/1042819031000123447.
Interferon-alpha (INF-alpha) is an effective anti-neoplastic and anti-viral drug. Treatment with INF-alpha is frequently complicated by adverse effects, which may rarely be immune mediated. We report 2 patients with Ph+ chronic myeloid leukemia (CML) who developed autoimmune thrombocytopenia while receiving months of treatment with INF-alpha. This complication responded well to discontinuation of interferon and administration of steroids treatment. Here, we also summarize the literature on INF-alpha induced autoimmune thrombocytopenia, and discuss differential diagnosis and possible mechanisms involved in the development of thrombocytopenia during therapy with INF-alpha.
干扰素-α（INF-α）是一种有效的抗肿瘤和抗病毒药物。使用INF-α治疗常常会出现不良反应，其中免疫介导的不良反应较为罕见。我们报告了2例Ph+慢性髓性白血病（CML）患者，他们在接受数月的INF-α治疗后出现了自身免疫性血小板减少症。这种并发症在停用干扰素并给予类固醇治疗后反应良好。在此，我们还总结了关于INF-α诱导的自身免疫性血小板减少症的文献，并讨论了鉴别诊断以及INF-α治疗期间血小板减少症发生的可能机制。
