α干扰素在一名费城染色体阳性慢性髓性白血病且T淋巴细胞细胞遗传学正常的患者中诱发自身免疫性肝炎。
Interferon-alpha induced autoimmune hepatitis in a patient with Philadelphia chromosome-positive chronic myeloid leukemia with cytogenetically normal T lymphocytes.
作者信息
Ariad S, Song E, Cohen R, Bezwoda W R
机构信息
Department of Medicine, Johannesburg Hospital, University of the Witwatersrand, South Africa.
出版信息
Mol Biother. 1992 Sep;4(3):139-42.
PMID:1445668
Abstract
We report the occurrence of autoimmune hepatitis after treatment with interferon-alpha in a patient with Philadelphia chromosome-positive chronic myeloid leukemia. Cytogenetic and molecular genetic studies of the T lymphocytes in this patient demonstrated that the T lymphocytes were not part of the leukemic clone. The role of interferon in the production of autoimmune abnormalities is reviewed.
摘要
我们报告了1例费城染色体阳性慢性髓性白血病患者在接受α干扰素治疗后发生自身免疫性肝炎的病例。对该患者T淋巴细胞进行的细胞遗传学和分子遗传学研究表明，这些T淋巴细胞并非白血病克隆的一部分。本文对干扰素在自身免疫异常发生中的作用进行了综述。
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