Zheng Zhi, Pan Tie-Cheng, Li Jun, Chen Tao, Song Ding-Wei, Yi Jun
Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Ai Zheng. 2004 Feb;23(2):185-8.
BACKGROUND & OBJECTIVE: Lymph node metastasis is an important factor for prognosis of non-small cell lung cancer (NSCLC). There were different opinions about what effect does lymph node micrometastasis have on prognosis. This study was designed to collect literatures of lymph node micrometastasis and prognosis in stage I NSCLC patients, in order to investigate their relationship.
The results from eight literatures on lymph node micrometastasis and prognosis from 1980 to 2002 were analyzed synthetically by meta-analysis. The cumulative cases were 536 NSCLC patients with stage I disease.
The detection rate of lymph node micrometastasis ranged from 3.4% to 28.9%, and the rate of positive cases ranged from 20% to 70%. The 3-, 5-year over-survival rate for positive lymph node micrometastasis patients was worse than those of negative lymph node micrometastasis patients: odd ratios (ORs) were 4.16 (95%CI:2.32-7.46) and 3.57 (95%CI:2.30-5.53), respectively (P< 0.01).
Positive lymph node micrometastasis may be an adverse factor for post-operative prognosis of NSCLC stage I patients.
淋巴结转移是非小细胞肺癌（NSCLC）预后的重要因素。关于淋巴结微转移对预后有何影响存在不同观点。本研究旨在收集Ⅰ期NSCLC患者淋巴结微转移与预后的文献，以探讨它们之间的关系。
采用Meta分析综合分析1980年至2002年8篇关于淋巴结微转移与预后的文献结果。累积病例为536例Ⅰ期NSCLC患者。
淋巴结微转移的检出率为3.4%至28.9%，阳性病例率为20%至70%。淋巴结微转移阳性患者的3年、5年总生存率低于微转移阴性患者：比值比（OR）分别为4.16（95%CI：2.32 - 7.46）和3.57（95%CI：2.30 - 5.53）（P < 0.01）。
淋巴结微转移阳性可能是Ⅰ期NSCLC患者术后预后的不利因素。
