Chen Long, Yu Fenglei
Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Zhongguo Fei Ai Za Zhi. 2011 Oct;14(10):830-4. doi: 10.3779/j.issn.1009-3419.2011.10.11.
The bromodomain-containing protein 7 (BRD7) gene belongs to the bromodomain family. The majority of the members of this family are closely related to epithelial tumors. The aim of this study is to explore BRD7 expression and its clinical significance in non-small cell lung cancer (NSCLC).
BRD7 protein expression was detected in tissues samples from 101 NSCLC cases and 33 normal lung tissue samples using streptavidin-peroxidase immunohistochemistry.
BRD7 expression was significantly higher in cancer tissues than that in normal lung tissues. Positive BRD7 expression in the lymph node metastasis group was significantly higher than that in the non-lymph node metastasis group. The positive expression rate of BRD7 increased with the increasing Tumor-Nodes-Metastasis (TNM) stage. No significant differences in positive BRD7 expression were observed with age, smoking, gender, pathology type, and degree of differentiation among the NSCLC patients (P>0.05).
BRD7 is highly expressed in NSCLC. In addition to the degree of differentiation and extent of lymphatic metastasis, BRD7 expression is correlated with TNM stage, which indicates that BRD7 may be related to the occurrence, development, and metastasis of lung cancers.
含溴结构域蛋白7（BRD7）基因属于溴结构域家族。该家族的大多数成员与上皮性肿瘤密切相关。本研究旨在探讨BRD7在非小细胞肺癌（NSCLC）中的表达及其临床意义。
采用链霉亲和素-过氧化物酶免疫组织化学法检测101例NSCLC组织样本和33例正常肺组织样本中BRD7蛋白的表达。
癌组织中BRD7的表达明显高于正常肺组织。淋巴结转移组BRD7阳性表达明显高于非淋巴结转移组。BRD7阳性表达率随肿瘤-淋巴结-转移（TNM）分期的增加而升高。NSCLC患者的年龄、吸烟情况、性别、病理类型及分化程度在BRD7阳性表达上无显著差异（P>0.05）。
BRD7在NSCLC中高表达。除分化程度和淋巴转移范围外，BRD7表达与TNM分期相关，这表明BRD7可能与肺癌的发生、发展及转移有关。
