Madsen Jan L, Graff Jesper
Department of Clinical Physiology and Nuclear Medicine 239, Hvidovre Hospital, University Hospital of Copenhagen, Kettegård Allé 30, DK-2650 Hvidovre, Copenhagen, Denmark.
Age Ageing. 2004 Mar;33(2):154-9. doi: 10.1093/ageing/afh040.
Existing data on the effect of ageing on gastrointestinal motility are few. In this study, we assessed the propulsive effect of all main segments of the gastrointestinal tract in a group of healthy older people.
16 healthy volunteers (eight women, eight men) of mean age 81 years (range 74-85 years) participated in the study. Gastric emptying and small intestinal and colonic transit rates were determined by gamma camera technique. The technique was also used to measure the postprandial frequency of antral contractions. Furthermore, we assessed the effects of gender, body mass index and smoking on the motility variables. The results were compared with data from 16 healthy individuals (eight women, eight men) of mean age 24 years (range 20-30 years).
Advanced age did not influence gastric emptying or small intestinal transit rate. Older individuals had a slower colonic transit than young individuals (P = 0.0008). No difference was found in postprandial frequency of antral contractions between older and young subjects. None of the motility variables was affected by gender or body mass index. Smokers had a faster colonic transit than non-smokers (P = 0.0022).
Normal ageing seems to reduce the propulsive capacity of the colon, whereas gastric and small intestinal motility is not affected.
关于衰老对胃肠动力影响的现有数据很少。在本研究中，我们评估了一组健康老年人胃肠道所有主要节段的推进作用。
16名平均年龄81岁（范围74 - 85岁）的健康志愿者（8名女性，8名男性）参与了研究。通过γ相机技术测定胃排空、小肠和结肠转运速率。该技术还用于测量餐后胃窦收缩频率。此外，我们评估了性别、体重指数和吸烟对动力变量的影响。将结果与16名平均年龄24岁（范围20 - 30岁）的健康个体（8名女性，8名男性）的数据进行比较。
高龄不影响胃排空或小肠转运速率。老年人的结肠转运比年轻人慢（P = 0.0008）。老年和年轻受试者之间餐后胃窦收缩频率没有差异。动力变量均不受性别或体重指数影响。吸烟者的结肠转运比不吸烟者快（P = 0.0022）。
正常衰老似乎会降低结肠的推进能力，而胃和小肠动力不受影响。
