Madsen J L
Department of Clinical Physiology and Nuclear Medicine KF, Rigshospitalet, Copenhagen, Denmark.
Dig Dis Sci. 1992 Oct;37(10):1548-53. doi: 10.1007/BF01296501.
This study aimed to assess separately the effects of gender, age, and body mass index on gastric emptying, small intestinal transit, and colonic transit times of a meal containing 99mTc-labeled cellulose fiber and 2- to 3-mm 111In-labeled plastic particles. Seventeen healthy young subjects (nine men; eight women; age 21-27 years; body mass index 18.4-25.1 kg/m2) and 16 healthy older subjects (eight men; eight women; age 55-74 years; body mass index 19.8-36.0 kg/m2) were studied. All transit variables were unaffected by gender. The older subjects had a slower mean colonic transit time of radiolabeled plastic particles than the young subjects (P < 0.05). Age did not affect mean gastric emptying or mean small intestinal transit times of the radiolabeled markers. An inverse association was found between body mass index and mean gastric emptying time of radiolabeled cellulose fiber (P < 0.02). Body mass index had no influence on other transit variables. The study revealed a considerable intersubject and a somewhat smaller intrasubject variability in mean gastric emptying, mean small intestinal, and mean colonic transit times.
本研究旨在分别评估性别、年龄和体重指数对含有99mTc标记的纤维素纤维及2至3毫米111In标记的塑料颗粒餐食的胃排空、小肠转运及结肠转运时间的影响。研究了17名健康年轻受试者（9名男性，8名女性；年龄21 - 27岁；体重指数18.4 - 25.1 kg/m²）和16名健康老年受试者（8名男性，8名女性；年龄55 - 74岁；体重指数19.8 - 36.0 kg/m²）。所有转运变量均不受性别的影响。老年受试者放射性标记塑料颗粒的平均结肠转运时间比年轻受试者慢（P < 0.05）。年龄不影响放射性标记物的平均胃排空或平均小肠转运时间。体重指数与放射性标记纤维素纤维的平均胃排空时间呈负相关（P < 0.02）。体重指数对其他转运变量无影响。该研究揭示了平均胃排空、平均小肠和平均结肠转运时间在受试者间存在相当大的变异性，而受试者内的变异性略小。
