一种通用、选择性高、产率高的叔胺N-去甲基化方法，采用固体试剂，在类似柱色谱的简便装置中进行。

A general, selective, high-yield N-demethylation procedure for tertiary amines by solid reagents in a convenient column chromatography-like setup.

作者信息

Rosenau Thomas, Hofinger Andreas, Potthast Antje, Kosma Paul

机构信息

Institute of Chemistry, Christian-Doppler Laboratory, University of Natural Resources and Applied Life Sciences, Vienna, Austria. thomas.rosenau@.boku.ac.at

出版信息

Org Lett. 2004 Feb 19;6(4):541-4. doi: 10.1021/ol036319g.

DOI:10.1021/ol036319g

PMID:14961618

Abstract

[reaction: see text] A traditional preparative chromatographic column can be used to achieve quantitative N-demethylation of tertiary N-methylamines and alkaloids. The filling is the crucial part and is loaded with different solid reagents in three reaction zones. The parent compound is charged on the column, and the neat N-demethylated secondary amine leaves the column some minutes later.

摘要

[反应：见正文] 传统的制备色谱柱可用于实现叔胺N-甲基和生物碱的定量N-去甲基化。填充物是关键部分，在三个反应区装填不同的固体试剂。将母体化合物装入柱中，纯净的N-去甲基化仲胺在几分钟后离开色谱柱。