Afonso Carlos A M, Lourenço Nuno M T, Rosatella Andreia de A
CQFM, Departamento de Engenharia Química, Instituto Superior Técnico, 1049-001 Lisboa, Portugal.
Molecules. 2006 Jan 31;11(1):81-102. doi: 10.3390/11010081.
Several specific synthetic protocols were developed for the preparation from cyanuric chloride of a range of symmetric and non-symmetric di- and tri-substituted 1,3,5-triazines containing alkyl, aromatic, hindered, chiral and achiral hydroxyalkyl, ester and imidazole groups via sequential nucleophilic substitution of the C-Cl bond by C-O, C-N and C-S bonds.
通过碳 - 氯键依次被碳 - 氧键、碳 - 氮键和碳 - 硫键进行亲核取代反应,已开发出几种特定的合成方案,用于从三聚氯氰制备一系列含有烷基、芳基、受阻基、手性和非手性羟烷基、酯基和咪唑基的对称和不对称二取代及三取代的1,3,5 - 三嗪。