扩展普默勒反应化学。通过咪唑衍生物的氧化环化合成（±）-二溴海绵抑素
Extending Pummerer reaction chemistry. Synthesis of (+/-)-dibromophakellstatin by oxidative cyclization of an imidazole derivative.
作者信息
Feldman Ken S, Skoumbourdis Amanda P
机构信息
Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
出版信息
Org Lett. 2005 Mar 3;7(5):929-31. doi: 10.1021/ol0500113.
PMID:15727477
Abstract
The diastereoselective oxidative cyclization of a dihydrooroidin derivative is reported. The thioimidate product formed by application of a new variant of the Pummerer reaction serves as a precursor to dibromophakellstatin. [reaction: see text]
摘要
报道了一种二氢海鞘素衍生物的非对映选择性氧化环化反应。通过应用Pummerer反应的新变体形成的硫代亚胺酸酯产物可作为二溴海鞘素他汀的前体。[反应：见正文]
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