夸休可尔症血清对体外淋巴细胞转化的影响。
The effects of kwashiorkor serum on lymphocyte transformation in vitro.
作者信息
Beatty D W, Dowdle E B
出版信息
Clin Exp Immunol. 1978 Apr;32(1):134-43.
The serum from twelve children with kwashiorkor was deficient in its ability to support lymphocyte transformation in vitro, whereas lymphocytes from these children responded to phytohaemagglutinin and al-ogeneic lymphocytes in a relatively normal manner when cultured in normal serum. This serum abnormality improved with therapy and could not be clearly correlated with the degree of malnutrition, the presence or absence of infection or other laboratory manifestations of kwashiorkor. These observations indicate that defective cellular immune reactions in kwashiorkor may be symptomatic of a lack of some humoral factor and do not necessarily reflect an intrinsic cellular defect.
12名夸休可尔症患儿的血清在体外支持淋巴细胞转化的能力方面存在缺陷，然而，当在正常血清中培养时，这些患儿的淋巴细胞对植物血凝素和同种异基因淋巴细胞的反应相对正常。这种血清异常随着治疗而改善，并且与营养不良的程度、是否存在感染或夸休可尔症的其他实验室表现没有明显关联。这些观察结果表明，夸休可尔症中细胞免疫反应缺陷可能是某种体液因子缺乏的症状，不一定反映内在的细胞缺陷。
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