夸休可尔症血清对体外淋巴细胞转化的影响。
The effects of kwashiorkor serum on lymphocyte transformation in vitro.
作者信息
Beatty D W, Dowdle E B
出版信息
Clin Exp Immunol. 1978 Apr;32(1):134-43.
Abstract
The serum from twelve children with kwashiorkor was deficient in its ability to support lymphocyte transformation in vitro, whereas lymphocytes from these children responded to phytohaemagglutinin and al-ogeneic lymphocytes in a relatively normal manner when cultured in normal serum. This serum abnormality improved with therapy and could not be clearly correlated with the degree of malnutrition, the presence or absence of infection or other laboratory manifestations of kwashiorkor. These observations indicate that defective cellular immune reactions in kwashiorkor may be symptomatic of a lack of some humoral factor and do not necessarily reflect an intrinsic cellular defect.
摘要
12名夸休可尔症患儿的血清在体外支持淋巴细胞转化的能力方面存在缺陷，然而，当在正常血清中培养时，这些患儿的淋巴细胞对植物血凝素和同种异基因淋巴细胞的反应相对正常。这种血清异常随着治疗而改善，并且与营养不良的程度、是否存在感染或夸休可尔症的其他实验室表现没有明显关联。这些观察结果表明，夸休可尔症中细胞免疫反应缺陷可能是某种体液因子缺乏的症状，不一定反映内在的细胞缺陷。
相似文献
1
The effects of kwashiorkor serum on lymphocyte transformation in vitro.夸休可尔症血清对体外淋巴细胞转化的影响。
Clin Exp Immunol. 1978 Apr;32(1):134-43.
2
Deficiency in kwashiorkor serum of factors required for optimal lymphocyte transformation in vitro.夸希奥科病血清中缺乏体外最佳淋巴细胞转化所需的因子。
Clin Exp Immunol. 1979 Mar;35(3):433-42.
3
Effect of levamisole on E rosette inhibition by serum of malnourished children.
Biomed Pharmacother. 1983;37(6):276-80.
4
Defective leucocyte inhibitory factor (LIF) production by lymphocytes in children with kwashiorkor.夸休可尔症患儿淋巴细胞产生白细胞抑制因子（LIF）存在缺陷。
S Afr Med J. 1976 Oct 12;50(45):1820-2.
5
6
Impaired cellular immunity in kwashiorkor with improvement after therapy.夸希奥科病患者存在细胞免疫受损，治疗后有所改善。
Br Med J. 1971 Nov 27;4(5786):527-9. doi: 10.1136/bmj.4.5786.527.
7
Thymus-derived lymphocyte levels in children with protein-energy-malnutrition (kwashiorkor).
East Afr Med J. 1980 Dec;57(12):833-42.
8
9
Leucocyte migration inhibition factor (L-MIF) in malnourished Nigerian children.营养不良的尼日利亚儿童体内的白细胞游走抑制因子（L-MIF）
Afr J Med Med Sci. 1999 Mar-Jun;28(1-2):17-20.
10
Immunity to measles in malnourished children.营养不良儿童对麻疹的免疫力。
Clin Exp Immunol. 1980 Oct;42(1):144-51.
引用本文的文献
1
The immune system in children with malnutrition--a systematic review.营养不良儿童的免疫系统——一项系统综述。
PLoS One. 2014 Aug 25;9(8):e105017. doi: 10.1371/journal.pone.0105017. eCollection 2014.
2
Alteration of cell-mediated immunity to Listeria monocytogenes in protein-malnourished mice treated with thymosin fraction V.用胸腺素组分V治疗的蛋白质营养不良小鼠对单核细胞增生李斯特菌的细胞介导免疫的改变
Infect Immun. 1982 Aug;37(2):601-8. doi: 10.1128/iai.37.2.601-608.1982.
3
Cell mediated immunity in idiopathic glomerulonephritis.特发性肾小球肾炎中的细胞介导免疫
Clin Exp Immunol. 1981 Oct;46(1):27-34.
4
A controlled trial of treatment of acquired immunodeficiency in severe measles with thymic humoral factor.用胸腺体液因子治疗重症麻疹获得性免疫缺陷的对照试验。
Clin Exp Immunol. 1984 Jun;56(3):479-85.
5
Numerical and functional deficiency in T helper cells in protein energy malnutrition.蛋白质能量营养不良时辅助性T细胞的数量和功能缺陷。
Clin Exp Immunol. 1983 Jan;51(1):126-32.
6
Immunity to measles in malnourished children.营养不良儿童对麻疹的免疫力。
Clin Exp Immunol. 1980 Oct;42(1):144-51.
7
Plasma cell infiltration of the small bowel: lack of evidence for a non-secretory form of alpha-heavy chain disease.小肠浆细胞浸润：缺乏非分泌型α重链病的证据。
Gut. 1985 Sep;26(9):928-34. doi: 10.1136/gut.26.9.928.
8
Deficiency in kwashiorkor serum of factors required for optimal lymphocyte transformation in vitro.夸希奥科病血清中缺乏体外最佳淋巴细胞转化所需的因子。
Clin Exp Immunol. 1979 Mar;35(3):433-42.
本文引用的文献
1
TUBERCULIN SENSITIVITY FOLLOWING B.C.G. VACCINATION IN UNDERNOURISHED CHILDREN.营养不良儿童接种卡介苗后的结核菌素敏感性
East Afr Med J. 1965 May;42:233-8.
2
ANTIGENIC STIMULATION IN UNDERNOURISHED CHILDREN.营养不良儿童的抗原刺激
East Afr Med J. 1965 May;42:221-32.
3
ANTIBODY RESPONSE IN KWASHIORKOR.夸希奥科病中的抗体反应。
Indian J Med Res. 1964 Nov;52:1154-8.
4
PHAGOCYTIC AND ALKALINE PHOSPHATASE ACTIVITY OF LEUKOCYTES IN KWASHIORKOR.夸希奥科病中白细胞的吞噬及碱性磷酸酶活性
J Pediatr. 1964 May;64:753-61. doi: 10.1016/s0022-3476(64)80625-9.
5
Antibody response in children with protein malnutrition.蛋白质营养不良儿童的抗体反应。
Am J Clin Nutr. 1962 May;10:379-83. doi: 10.1093/ajcn/10.5.379.
6
Changes in intestinal bacterial flora and role of infection in kwashiorkor.夸希奥科病中肠道细菌菌群的变化及感染的作用。
Lancet. 1958 Oct 4;2(7049):724-7. doi: 10.1016/s0140-6736(58)91336-9.
7
Some observations on the development of kwashiorkor; a study of 205 cases.关于夸休可尔症发展的一些观察；205例病例研究。
S Afr Med J. 1956 Apr 28;30(17):396-9.
8
Carbohydrate absorption in malnourished children.
Am J Clin Nutr. 1967 Feb;20(2):89-97. doi: 10.1093/ajcn/20.2.89.
9
Acute bacterial infection in kwashiorkor and marasmus.夸希奥科病和消瘦症中的急性细菌感染。
Br Med J. 1968 Feb 17;1(5589):407-9. doi: 10.1136/bmj.1.5589.407.
10
Thymus weights in malnourished children.
J Trop Pediatr (1967). 1969 Dec;15(4):155-8. doi: 10.1093/tropej/15.4.155.
Zotero 插件