Petro T M, Chien G, Watson R R
Infect Immun. 1982 Aug;37(2):601-8. doi: 10.1128/iai.37.2.601-608.1982.
Cell-mediated immune reactivity, measured by lymphocyte responsiveness to phytohemagglutinin, was higher in both young or aged mice fed a 4% casein diet compared with age-matched controls. Treatment in vivo with bovine thymosin fraction V decreased the responsiveness to phytohemagglutinin of lymphocytes from mice fed either the control or moderately protein-deficient diets when compared with mice treated in vivo with saline. Resistance against Listeria monocytogenes, known to be a cell-mediated immune function, was impaired in young and aged mice which were fed the low-protein diet. Treatment with thymosin was able to significantly improve the cell-mediated immune resistance to L. monocytogenes of moderately protein-malnourished mice. Thymosin treatment impaired the resistance to L. monocytogenes of young or aged mice fed the control diet. The splenic natural killer cell cytotoxicity of protein-malnourished mice was impaired compared with that of mice fed the control diet. Treatment with thymosin did not restore the natural killer cell cytotoxic activity in protein-malnourished mice, but did enhance that activity in control mice.
通过淋巴细胞对植物血凝素的反应性来衡量的细胞介导免疫反应性，在喂食4%酪蛋白饮食的年轻或老年小鼠中，均高于年龄匹配的对照组。与用生理盐水进行体内处理的小鼠相比，用牛胸腺素组分V进行体内处理会降低喂食对照饮食或中度蛋白质缺乏饮食的小鼠淋巴细胞对植物血凝素的反应性。已知对单核细胞增生李斯特菌的抵抗力是一种细胞介导的免疫功能，在喂食低蛋白饮食的年轻和老年小鼠中受到损害。用胸腺素治疗能够显著提高中度蛋白质营养不良小鼠对单核细胞增生李斯特菌的细胞介导免疫抵抗力。胸腺素治疗会损害喂食对照饮食的年轻或老年小鼠对单核细胞增生李斯特菌的抵抗力。与喂食对照饮食的小鼠相比，蛋白质营养不良小鼠的脾脏自然杀伤细胞细胞毒性受到损害。用胸腺素治疗并未恢复蛋白质营养不良小鼠的自然杀伤细胞细胞毒性活性，但确实增强了对照小鼠的该活性。
