VARAN：一个用于DNA微阵列实验变异性分析的网络服务器。
VARAN: a web server for variability analysis of DNA microarray experiments.
作者信息
Golfier G, Dang M Tran, Dauphinot L, Graison E, Rossier J, Potier M-C
机构信息
Neurobiologie et Diversité Cellulaire, CNRS UMR7637, Ecole Supérieure de Physique et de Chimie Industrielles, 10 rue Vauquelin, 75005 Paris, France.
出版信息
Bioinformatics. 2004 Jul 10;20(10):1641-3. doi: 10.1093/bioinformatics/bth117. Epub 2004 Feb 12.
UNLABELLED
Here, we describe a tool for VARiability Analysis of DNA microarrays experiments (VARAN), a freely available Web server that performs a signal intensity based analysis of the log2 expression ratio variability deduced from DNA microarray data (one or two channels). Two modules are proposed: VARAN generator to compute a sliding windows analysis of the experimental variability (mean and SD) and VARAN analyzer to compare experimental data with an asymptotic variability model previously built with the generator module from control experiments. Both modules provide normalized intensity signals with five possible methods, log ratio values and a list of genes showing significant variations between conditions.
AVAILABILITY
http://www.bionet.espci.fr/varan/
SUPPLEMENTARY INFORMATION
未标注
在此，我们描述了一种用于DNA微阵列实验变异性分析的工具（VARAN），这是一个免费的网络服务器，它基于信号强度对从DNA微阵列数据（单通道或双通道）推导得出的log2表达比率变异性进行分析。我们提出了两个模块：VARAN生成器，用于计算实验变异性（均值和标准差）的滑动窗口分析；VARAN分析器，用于将实验数据与先前使用生成器模块从对照实验构建的渐近变异性模型进行比较。两个模块都提供了五种可能方法的归一化强度信号、log比率值以及显示不同条件之间显著差异的基因列表。
可用性
http://www.bionet.espci.fr/varan/
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