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Activation of transcription factors by interferon-alpha in a cell-free system.

作者信息

David M, Larner A C

机构信息

Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, MD 20892.

出版信息

Science. 1992 Aug 7;257(5071):813-5. doi: 10.1126/science.1496402.

DOI:10.1126/science.1496402
PMID:1496402
Abstract

The signal transduction mechanisms of interferons (IFNs) remain unclear partly because no effect of IFN has been reproducible in a cell-free system. IFN-alpha rapidly induces the transcription of a set of early response genes, and a multicomponent transcriptional activator, interferon stimulated gene factor 3 (ISGF3), is activated within minutes after binding of IFN-alpha to its receptor. A system was developed in which IFN-alpha activated ISGF3 in homogenates of HeLa cells. Subcellular fractionation revealed that incubation of a plasma membrane-enriched fraction with IFN-alpha was sufficient to activate the regulatory subcomponent of ISGF3.

摘要

相似文献

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EMBO J. 1996 Apr 1;15(7):1566-71.
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Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor.JAKs在表皮生长因子激活STATs及刺激c-fos基因表达中的作用。
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