Benowitz N L
Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco.
Occup Med. 1992 Jul-Sep;7(3):465-78.
A number of chemicals have been implicated in the causation of cardiovascular disease, although often in individual patients causality for any specific toxic exposure is difficult to establish. This review discusses toxic cardiovascular disease from specific toxins from the perspective of the types of injury and details epidemiology, mechanisms of toxicity, and clinical features. Discussed are carbon disulfide, carbon monoxide, organic nitrates, halogenated hydrocarbons, lead, cobalt, arsenic/arsine, and cadmium and antimony.
尽管对于个别患者而言,很难确定任何特定有毒物质暴露与心血管疾病之间的因果关系,但已有多种化学物质被认为与心血管疾病的发生有关。本综述从损伤类型的角度探讨了特定毒素导致的中毒性心血管疾病,并详细阐述了流行病学、毒性机制和临床特征。所讨论的毒素包括二硫化碳、一氧化碳、有机硝酸盐、卤代烃、铅、钴、砷/胂,以及镉和锑。