Kaliman P A, Oksenenko S V
Karasin Kharkov National University, Ukraine.
Ukr Biokhim Zh (1999). 2002 Jul-Aug;74(4):102-8.
The influence of mercury chloride on peroxidation processes of lipids and level of common lipids, phospholipids and spectrum of neutral lipids in liver, heart, lung and kidney of rats has been investigated. Administration of mercury chloride in a dose 0.7 mg/100 g of body weight to animals has invoked accumulation of lipids peroxide products in fractions of neutral lipids and phospholipids so it testifies the development of oxidative stress. Decrease of the most sensitive to oxidation fractions in the early stages of oxidative stress development and increase of free cholesterol and its ethers content in kidney and free cholesterol in the heart in more later terms as a result of mercury chloride administration have been revealed.
研究了氯化汞对大鼠肝脏、心脏、肺和肾脏中脂质过氧化过程以及总脂质、磷脂和中性脂质谱水平的影响。给动物施用剂量为0.7mg/100g体重的氯化汞，会引起中性脂质和磷脂组分中脂质过氧化物产物的积累，这证明了氧化应激的发展。已经发现，由于施用氯化汞，在氧化应激发展的早期阶段，对氧化最敏感的组分减少，而在更后期，肾脏中游离胆固醇及其醚类含量增加，心脏中游离胆固醇增加。
