[Effect of cyclophosphane on lipid peroxidation].

Single and repeated treatment with toxic doses of cyclophosphamide was shown to activate peroxidation of lipids of myocardial, pulmonary, hepatic and renal cell membranes. An antioxidant-silymarin-inhibited the prooxidating effect of cyclophosphamide thus suggesting further studies of antioxidants as means for counteracting the adverse effects of cytostatic drugs.