Kogan E A, Bondarenko O Iu, Sklianskaia O A, Lapina T L, Demura S A, Azov A G, Ivashkin V T
I. M. Sechenov Moscow Medical Academy, 119881, Moscow.
Arkh Patol. 2003 Nov-Dec;65(6):22-6.
77 patients with chronic Helicobacter gastritis verified endoscopically and exacerbation of duodenal ulcer were examined. H. pylori infection was identified by the rapid ureasa test (CLO-test) and Giemza staining. The patients received 7-day three-component therapy for eradication of H. pylori. Apoptosis and proliferation were studied in 16 patients in serial sections with the use of monoclonal antibodies. Eradication of H. pylori resulted in relief of inflammation and transformation of active gastritis in inactive one. H. pylori-associated gastritis is associated with activation of apoptosis of gastric mucosa epithelial cells and epitheliocytes proliferation. H. pylori eradication alters correlation between apoptosis of epitheliocytes and their proliferation: successful eradication of the infection decreases apoptosis, high proliferative activity of epitheliocytes persists reflecting enhancement of regeneration in gastric mucosa.
对77例经内镜检查确诊为慢性幽门螺杆菌胃炎且十二指肠溃疡加重的患者进行了检查。通过快速尿素酶试验（CLO试验）和吉姆萨染色鉴定幽门螺杆菌感染。患者接受了为期7天的三联疗法以根除幽门螺杆菌。使用单克隆抗体对16例患者的连续切片进行了凋亡和增殖研究。根除幽门螺杆菌可减轻炎症并使活动性胃炎转变为非活动性胃炎。幽门螺杆菌相关性胃炎与胃黏膜上皮细胞凋亡激活和上皮细胞增殖有关。根除幽门螺杆菌改变了上皮细胞凋亡与其增殖之间的相关性：成功根除感染可减少凋亡，上皮细胞的高增殖活性持续存在，反映出胃黏膜再生增强。
