Korkushko O V, Pysaruk A V, Lishnevs'ka V Iu, Romanenko M S
Lik Sprava. 2003 Dec(8):8-11.
Forty-eight elderly patients with IHD and paroxysmal atrial fibrillation were studied to determine circadian pattern of arrhythmia onset. The data were obtained by detailed interview and analysis of medical documents. The found variations were fitted to cosinusoidal function with a period of 24 hours Y = 9.75 + 3.5cos(2 pi t/24 + 0.2) (R2 = 0.69; F = 10.2; P < 0.01; two first coefficients of equation are significant by t-test, P < 0.01), the peak of arrhythmia onset was observed about midnight. 59.8% of overall number of episodes developed at dark period of day (P < 0.05). Findings testify that time periods of arrhythmia onset increase in number with disease evolution. It may be an additional criterion of paroxysmal atrial fibrillation transformation into its permanent form.
对48例患有缺血性心脏病和阵发性心房颤动的老年患者进行了研究，以确定心律失常发作的昼夜模式。数据通过详细访谈和病历分析获得。发现的变化拟合为周期为24小时的余弦函数Y = 9.75 + 3.5cos(2πt/24 + 0.2)（R2 = 0.69；F = 10.2；P < 0.01；方程的前两个系数经t检验具有显著性，P < 0.01），心律失常发作高峰出现在午夜左右。59.8%的发作总数发生在白天的黑暗时段（P < 0.05）。研究结果表明，随着疾病进展，心律失常发作的时间段数量增加。这可能是阵发性心房颤动转变为持续性心房颤动的一个额外标准。
