Ganry O, Tramier B, Fardellone P, Raverdy N, Dubreuil A
Medical Information Department, CHU Amiens, France.
Breast. 2001 Aug;10(4):313-7. doi: 10.1054/brst.2000.0247.
Bone mass has been proposed as a marker of cumulative exposure to oestrogen in women. We have studied the association between bone mass and breast cancer in postmenopausal women. In 126 cases of breast cancers and 126 controls, the bone mineral density (BMD) of the lumbar spine (L2-L4), femoral neck, trochanter and Ward's triangle was measured by dual-energy X-ray absorptiometry. All cases of cancer were confirmed by pathological reports. A questionnaire including information on reproductive history and other variables was collected. BMD was significantly higher among breast cancer patients than controls at all sites, except at the femoral neck where BMD was increased in the cancer group, but not significantly. After adjustment for potential confounding factors, the estimated relative risk of breast cancer in the highest quartile of BMD compared to the lowest quartile ranged from 2.5 to 4.8 for various sites of measurement. These results confirm that bone-mass density is a strong predictor for breast cancer in postmenopausal women. Women in the lowest quartile of bone mass appear to be protected against breast cancer. The mechanisms underlying this relation may be explained by cumulative exposure to oestrogen.
骨量已被提议作为女性雌激素累积暴露的一个指标。我们研究了绝经后女性骨量与乳腺癌之间的关联。在126例乳腺癌患者和126例对照中，采用双能X线吸收法测量腰椎（L2-L4）、股骨颈、大转子和Ward三角区的骨密度（BMD）。所有癌症病例均经病理报告证实。收集了一份包括生殖史和其他变量信息的问卷。除股骨颈外，乳腺癌患者在所有部位的骨密度均显著高于对照组，在股骨颈部位，癌症组骨密度有所增加，但不显著。在对潜在混杂因素进行调整后，与最低四分位数相比，BMD最高四分位数的乳腺癌估计相对风险在不同测量部位为2.5至4.8。这些结果证实，骨密度是绝经后女性乳腺癌的一个强有力的预测指标。骨量处于最低四分位数的女性似乎对乳腺癌具有防护作用。这种关系背后的机制可能可用雌激素的累积暴露来解释。
