Rajentheran R, Rao C M, Lim E, Lennard T W
North of Tyne Breast Group, Dept Surgery, University of Newcastle Upon Tyne, UK.
Breast. 2001 Oct;10(5):416-20. doi: 10.1054/brst.2000.0270.
We have evaluated tumour characteristics, local recurrence rates and prognostic markers in 40 women with symptomatic palpable breast cancer proven by cytology, but in whom routine two-view mammography failed to detect a radiological abnormality. False negative mammograms were identified by cross-referencing all negative mammograms performed at the Royal Victoria Infirmary during the period 1995-1999, with pathological records at the same institution. The average age was 48 years. The majority of the tumours were invasive ductal carcinomas, 35 with an average size of 24 mm. There were 16 Grade II and 15 Grade III tumours. Lymphovascular invasion was seen in 18 on histology and six patients had distant metastases. Of those patients treated by conservation therapy there has been only one local recurrence, with a median follow-up of 18 months. We conclude that mammographically invisible tumours are of common histological type, are frequently high grade and node positive and occur mainly in the younger age group. However, BCT remains a viable option in the treatment of these tumours.
我们评估了40例经细胞学证实有症状且可触及的乳腺癌女性患者的肿瘤特征、局部复发率和预后标志物，这些患者的常规双视图乳房X线摄影未能检测到放射学异常。通过将1995年至1999年期间在皇家维多利亚医院进行的所有阴性乳房X线摄影与同一机构的病理记录交叉对照，确定了假阴性乳房X线摄影。平均年龄为48岁。大多数肿瘤为浸润性导管癌，35例，平均大小为24mm。有16例II级肿瘤和15例III级肿瘤。组织学检查发现18例有淋巴管浸润，6例患者有远处转移。在接受保乳治疗的患者中，只有1例局部复发，中位随访时间为18个月。我们得出结论，乳房X线摄影不可见的肿瘤具有常见的组织学类型，通常分级较高且淋巴结阳性，主要发生在较年轻的年龄组。然而，保乳手术仍然是治疗这些肿瘤的可行选择。
