Sarazin F, Dompmartin A, Nivot S, Letessier D, Leroy D
Department of Dermatology, Centre Hospitalier Universitaire, Caen, France.
Eur J Dermatol. 2004 Jan-Feb;14(1):71-2.
We report the case of a little girl who presented with a nodulocystic acne which had its onset at the age of 20 months. She had no clinical or biological features of endocrinopathy. The lesions did not respond to conventional antibiotics so she was started on oral isotretinoin. A seven-month treatment period was necessary to achieve remission. The onset of infantile acne is usually around 6 to 16 months and there is a male predominance. The onset is later in females. Oral erythromycin is the first line treatment when topical therapies are inefficacious. Some cystic lesions do not respond to oral antibiotics. In these cases, oral isotretinoin may be effective and the treatment is similar to that of an adult. Clinical and biological tolerance is good with no growth retardation. Lesions may relapse after the withdrawal of isotretinoin but they are less important and easily controlled with topical treatments. Isotretinoin can be used for nodulocystic acne to reduce the risk of scarring.
我们报告了一名小女孩的病例，她患有结节囊肿性痤疮，发病于20个月大时。她没有内分泌病的临床或生物学特征。这些皮损对传统抗生素无反应，因此开始口服异维A酸治疗。需要七个月的治疗期才能实现缓解。婴儿痤疮的发病通常在6至16个月左右，男性居多。女性发病较晚。当局部治疗无效时，口服红霉素是一线治疗方法。一些囊性皮损对口服抗生素无反应。在这些情况下，口服异维A酸可能有效，且治疗方法与成人相似。临床和生物学耐受性良好，无生长发育迟缓。停用异维A酸后皮损可能复发，但程度较轻，用局部治疗容易控制。异维A酸可用于结节囊肿性痤疮，以降低瘢痕形成的风险。
