Taniguchi M, Kato A, Ninomiya H, Hirata M, Cheyne D, Robinson S E, Maruno M, Saitoh Y, Kishima H, Yoshimine T
Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
J Neurol Neurosurg Psychiatry. 2004 Mar;75(3):466-71. doi: 10.1136/jnnp.2002.001834.
Application of spatially filtered magnetoencephalography (MEG) to investigate changes in the mechanism of cerebral motor control in patients with tumours around the central sulcus.
MEG records were made during a repetitive hand grasping task in six patients with gliomas around the central sulcus and in four control subjects. Power decreases in the alpha (8-13 Hz), beta (13-30 Hz), and low gamma bands (30-50 Hz) during the motor tasks (event related desynchronisation, ERD) were analysed statistically with synthetic aperture magnetometry. The tomography of ERD was superimposed on the individual's magnetic resonance image.
beta ERD was consistently localised to the contralateral primary sensorimotor cortex (MI/SI) in control subjects, whereas the alpha and low gamma ERD showed considerable intersubject variability. beta ERD in patients during non-affected side hand movement was also localised to the contralateral MI/SI, but exclusively to the ipsilateral hemisphere during affected side hand movement.
The altered pattern of ERD in the patient group during affected side hand movement suggests recruitment of diverse motor areas, especially the ipsilateral MI/SI, which may be required for the effective movement of the affected hand.
应用空间滤波脑磁图（MEG）研究中央沟周围肿瘤患者大脑运动控制机制的变化。
对6例中央沟周围胶质瘤患者和4例对照者在重复手部抓握任务期间进行MEG记录。使用合成孔径磁强计对运动任务期间（事件相关去同步化，ERD）α（8 - 13赫兹）、β（13 - 30赫兹）和低γ频段（30 - 50赫兹）的功率下降进行统计学分析。将ERD的断层扫描叠加在个体的磁共振图像上。
在对照者中，β ERD始终定位于对侧初级感觉运动皮层（MI/SI），而α和低γ ERD在个体间表现出相当大的变异性。患者在患侧手运动时，β ERD在健侧手运动期间也定位于对侧MI/SI，但在患侧手运动时仅定位于同侧半球。
患者组在患侧手运动期间ERD模式的改变表明多种运动区域被募集，尤其是同侧MI/SI，这可能是患侧手有效运动所必需的。
