Hopwood David A
John Innes Centre in Norwich, United Kingdom.
PLoS Biol. 2004 Feb;2(2):E35. doi: 10.1371/journal.pbio.0020035. Epub 2004 Feb 17.
Polyketides, natural products from microorganisms, have been a main source of antibiotics. Understanding the 'programming' of the enzymes that produce these complex molecules has opened a new field of drug discovery
聚酮化合物是微生物产生的天然产物,一直是抗生素的主要来源。了解产生这些复杂分子的酶的“编程”开启了药物发现的新领域。