Zhang You-meng, Su Yi, Jin Zhi-qin
Department of Stometoloy, Afilliated EENT Hospital of Fudan Univercity, Shanghai 200031, China.
Shanghai Kou Qiang Yi Xue. 2003 Oct;12(5):352-5.
The histologic and TNF-alpha changes of the experimental periodontitis were studied in diabetic rat model in different periods. The mechanism of the occurring and developing of periodontitis was probed on the aspect of cytology.
The diabetic rat models were established by injecting streptozotocin into its abdomen. The local stimulation was caused by tiring silk thread to teeth. The histologic changes of periodontium were observed at 6,9,and 12 weeks. The level of TNF-alpha was testified using immunohistochemistry method at 12 weeks.
Periodontitis occurred in diabetic rats earlier than in non-diabetic ones. The destructions were more severe and more widely in diabetic rats than in non-diabetic ones. The level of TNF-alpha was higher in the experimental periodontium of diabetic rats than those non-diabetics.
Diabetes mellitus has an accelerating effect on occurring and developing of periodontitis. When with diabetes, more cytokines were released, and cause the unbalance of ruin and repair and result in the enhancing of periodontitis.
研究不同时期糖尿病大鼠实验性牙周炎的组织学及肿瘤坏死因子-α（TNF-α）变化，从细胞学方面探讨牙周炎发生发展的机制。
通过腹腔注射链脲佐菌素建立糖尿病大鼠模型，用丝线结扎牙齿造成局部刺激，于6周、9周和12周观察牙周组织的组织学变化，12周时采用免疫组织化学方法检测TNF-α水平。
糖尿病大鼠牙周炎比非糖尿病大鼠发病早，破坏程度更严重、范围更广，糖尿病大鼠实验性牙周组织中TNF-α水平高于非糖尿病大鼠。
糖尿病对牙周炎的发生发展有加速作用，糖尿病状态下释放更多细胞因子，导致破坏与修复失衡，促使牙周炎加重。
