Hosalkar Harish S, Dormans John P
Pediatric Orthopedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4399, USA.
Pediatr Blood Cancer. 2004 Apr;42(4):295-310. doi: 10.1002/pbc.10406.
There has been an unprecedented improvement in the survival outcome of children with extremity sarcoma as well as a corresponding increase in percentage of limb-sparing surgeries being performed over the past many decades. This has been, in part, due to the improved imaging modalities, newer surgical techniques, and advences in neoadjuvant chemotherapy. Limb-sparing surgery for primary bone and soft-tissue malignancies in children is becoming an acceptable option of surgical treatment in most cases today. This article outlines the demographics, classification, clinical presentation, imaging, and molecular genetics of pediatric mosculoskeletal tumors and discusses the current treatment principles with emphasis on the state-of-the-art surgical management and limb-sparing techniques for children with extremity sarcoma.
在过去几十年中，肢体肉瘤患儿的生存结局有了前所未有的改善，同时保肢手术的实施比例也相应增加。这在一定程度上归功于成像方式的改进、更新的手术技术以及新辅助化疗的进展。如今，儿童原发性骨和软组织恶性肿瘤的保肢手术在大多数情况下正成为一种可接受的手术治疗选择。本文概述了儿童肌肉骨骼肿瘤的人口统计学、分类、临床表现、影像学及分子遗传学，并讨论了当前的治疗原则，重点是肢体肉瘤患儿的先进手术管理和保肢技术。
