Chou Kuei-Ru, Chen Ruey, Lee Jia-Fu, Ku Chih-Hung, Lu Ru-Band
National Defense Medical Center, School of Nursing, Nei-Hu, Taipei 114, Taiwan, ROC.
Int J Nurs Stud. 2004 Mar;41(3):321-30. doi: 10.1016/j.ijnurstu.2003.07.001.
The purpose of this study was to determine the effectiveness of nicotine-patch therapy for smoking cessation in patients with schizophrenia. This was a longitudinal study and sixty-eight schizophrenic patients were assigned to 8 weeks of a nicotine-patch therapy program or a control group. The generalized estimating equation analysis revealed that there were significant reductions in the subjects' nicotine dependence (Fagerstrom Tolerance Questionnaire), the number of cigarettes per day, and CO levels over an 8-week period of nicotine-patch therapy and 3-month follow-up. The point-prevalence rates of abstinence from smoking were an abstinence of 26.9% at 8 weeks and 26.9% at a 3-month follow-up. At the 3-month follow-up, the rate of continuous smoking abstinence in the nicotine-patch group was 23.1%.
本研究的目的是确定尼古丁贴片疗法对精神分裂症患者戒烟的有效性。这是一项纵向研究，68名精神分裂症患者被分配到为期8周的尼古丁贴片治疗项目组或对照组。广义估计方程分析显示，在为期8周的尼古丁贴片治疗及3个月的随访期间，受试者的尼古丁依赖程度（法格斯特罗姆耐受问卷）、每日吸烟量和一氧化碳水平均有显著降低。戒烟的时点患病率在8周时为26.9%，3个月随访时为26.9%。在3个月随访时，尼古丁贴片组持续戒烟率为23.1%。
