Kodaka Masato
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
Biophys Chem. 2004 Feb 15;107(3):243-53. doi: 10.1016/j.bpc.2003.09.013.
Requirements for generating remarkable sigmoidal time-course of aggregation are found in the nucleation-dependent polymerization model by a numerical calculation method; i.e. there are optimum values of the kinetic constants to afford prominent sigmoidal character by inducing slightly unfavorable nucleation. However, if the nucleus formation is too unfavorable, sigmoidal character is again decreased. This result is in contrast to the generally accepted idea that sigmoid is induced by thermodynamically unfavorable nucleation phase.
