Bock R E, de Vos A J, Kingston T G, Shiels I A, Dalgliesh R J
Tick Fever Research Centre, Queensland Department of Primary Industries, Wacol, Australia.
Vet Parasitol. 1992 Jun;43(1-2):45-56. doi: 10.1016/0304-4017(92)90047-d.
Field investigations of protection afforded by live Babesia bovis vaccine in Australia revealed that a ninefold increase in vaccine failures occurred in the period from 1985 to 1990. Laboratory trials using 189 experimental cattle were conducted to evaluate the protection afforded by the Babesia bovis strain used in the commercial vaccine during this time. Four isolates from clinical cases of babesiosis in vaccinated cattle were assessed. The results showed that the strain used in the vaccine during the 5 year period was poorly protective against three isolates while a recently isolated and prepared vaccine strain was strongly protective. Circumstantial evidence is provided that indicates the vaccine failures were due to change in the field populations of Babesia bovis, rather than change in the strain used in the vaccine. Implications of the results for the future of Babesia bovis vaccines are discussed.
澳大利亚对牛巴贝斯虫活疫苗所提供保护的现场调查显示，1985年至1990年期间疫苗失效情况增加了九倍。利用189头实验牛进行了实验室试验，以评估这一时期商业疫苗中使用的牛巴贝斯虫菌株所提供的保护。对来自接种疫苗牛的巴贝斯虫病临床病例的四个分离株进行了评估。结果表明，这5年期间疫苗中使用的菌株对三个分离株的保护作用较差，而最近分离和制备的疫苗菌株具有很强的保护作用。有间接证据表明疫苗失效是由于牛巴贝斯虫野外种群的变化，而非疫苗中使用的菌株发生了变化。文中讨论了这些结果对牛巴贝斯虫疫苗未来发展的影响。
