[外生殖器的分化与5α-还原酶]
[Differentiation of external genitalia and 5 alpha-reductase].
作者信息
Tohda Akira, Matsumoto Fumi, Shimada Kenji, Okuyama Akihiko
机构信息
Department of Urology, Osaka Medical Center, Research Institute for Maternal and Child Health.
出版信息
Nihon Rinsho. 2004 Feb;62(2):275-80.
Sexual differentiation of the external genitalia depends on many factors such as genetic sex, gonadal sex or androgen action. Among them, 5 alpha-reductase plays an important role in androgen action: dihydrotestosterone(DHT) is produce from testosterone by 5 alpha-reductase and DHT binds the androgen receptor to induce the differentiation of the external genitalia. In this paper we reviewed on the mechanism of the differentiation of the external genitalia, especially on the relation with androgen action and 5 alpha-reductase.
外生殖器的性分化取决于许多因素，如遗传性别、性腺性别或雄激素作用。其中，5α-还原酶在雄激素作用中起重要作用：5α-还原酶将睾酮转化为双氢睾酮（DHT），DHT与雄激素受体结合以诱导外生殖器的分化。本文综述了外生殖器分化的机制，特别是与雄激素作用和5α-还原酶的关系。
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