Jensen A L, Poulsen J S
Department of Clinical Studies, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
Zentralbl Veterinarmed A. 1992 Jun;39(5):342-8. doi: 10.1111/j.1439-0442.1992.tb00191.x.
The present study communicates the interim experience with the diagnostic value of the canine corticosteroid-induced alkaline phosphatase isoenzyme (CIAP), qualitatively assessed by agarose gel electrophoresis, for the diagnosis of Hypercorticism (prolonged exposure to increased concentrations of exogenous or endogenous corticosteroids) and Diabetes mellitus. A total of 106 canine serum samples with a total alkaline phosphatase activity greater than 2.90 mu kat/l were included. CIAP was identified in 28 out of 29 cases of Hypercorticism, in 7 out of 9 cases of Diabetes mellitus, and in 33 out of 68 cases of various other diseases. Sensitivity and specificity with respect to Hypercorticism were 0.97 and 0.48, respectively, while for Diabetes mellitus sensitivity and specificity were 0.78 and 0.37. From this, the positive and the negative predictive values were calculated using standard formulas. The main conclusion may be summarized as follows: In the dog, only the negative finding of CIAP seems to be of diagnostic value in ruling out Hypercorticism as a cause for an increased total alkaline phosphatase activity.
本研究报告了犬皮质类固醇诱导碱性磷酸酶同工酶（CIAP）诊断价值的中期经验，CIAP通过琼脂糖凝胶电泳进行定性评估，用于诊断皮质醇增多症（长期暴露于浓度升高的外源性或内源性皮质类固醇）和糖尿病。共纳入106份总碱性磷酸酶活性大于2.90微卡/升的犬血清样本。在29例皮质醇增多症病例中有28例检测到CIAP，在9例糖尿病病例中有7例检测到CIAP，在68例其他各种疾病病例中有33例检测到CIAP。相对于皮质醇增多症，敏感性和特异性分别为0.97和0.48，而对于糖尿病，敏感性和特异性分别为0.78和0.37。据此，使用标准公式计算出阳性和阴性预测值。主要结论可总结如下：在犬中，只有CIAP的阴性结果在排除皮质醇增多症作为总碱性磷酸酶活性升高原因方面似乎具有诊断价值。
