Bridges S L, Hughes L B, Mikuls T R, Howard G, Tiwari H K, Alarcón G S, McNicholl J M, Moreland L W
Departments of Medicine and Microbiology, Division of Clinical Immu-nology and Rheumatology, University of Alabama at Birmingham, 415 Lyons-Harrison Research Building, 701 19th Street South, Birmingham, Alabama 35294-0007, USA.
Clin Exp Rheumatol. 2003 Sep-Oct;21(5 Suppl 31):S138-45.
African-Americans have been under-represented in genetic studies of rheumatoid arthritis (RA) susceptibility and severity. Genetic and non-genetic factors influencing the radiographic severity of RA and its response to treatment are poorly understood, particularly in African-Americans. The Consortium for the Longitudinal Evaluation of African-Americans with early RA (CLEAR) Registry, a collaborative effort among four institutions in the southeast USA, will hopefully provide a useful resource to study these issues.
在类风湿性关节炎（RA）易感性和严重程度的基因研究中，非裔美国人的代表性不足。影响RA影像学严重程度及其对治疗反应的遗传和非遗传因素目前了解甚少，尤其是在非裔美国人中。美国东南部四个机构合作开展的早期RA非裔美国人纵向评估联盟（CLEAR）登记处，有望为研究这些问题提供有用的资源。
