Jankowska Renata, Kosacka Monika
Katedry i Kliniki Chorób Płuc Akademii Medycznej we Wrocławiu.
Wiad Lek. 2003;56(7-8):308-12.
Cancer cachexia syndrome is a common and important complication of cancer. It occurs in 30% to 80% cancer patients. It includes anorexia, loss weight, weakness and impaired immune function. The cause of the syndrome stays still unclear. Many endocrinological and metabolic abnormalities are observed, like hypermetabolism, glucose intolerance, increased proteolysis and lipolysis. Main role in the development of cancer cachexia is played by cytokines: TNF, interleukin 1 and 6, interferon alfa and gamma. The aim of the study was to collect information about cachexia in lung cancer patients, treated in Department of Pulmonology, Wrocław Medical University. We observed 76 patients with recent diagnosis of lung cancer (43 male, 33 female), 50 patients with non-small lung cancer and 26 with small lung cancer. Average age 61 +/- 9.76. We divided all patients in four groups, depending on percent of weight loss and compared these groups. We estimated extent of disease, anthropological and biochemical parameters. Among all patients we found cachexia in 23 (32%). There were only some differences between patients with and without cachexia. Bigger loss weight was observed in older men.
Cachexia syndrome is not an important problem in lung cancer patients at the time of diagnosis.
癌症恶病质综合征是癌症常见且重要的并发症。它发生在30%至80%的癌症患者中。其表现包括厌食、体重减轻、虚弱和免疫功能受损。该综合征的病因仍不清楚。观察到许多内分泌和代谢异常，如高代谢、葡萄糖不耐受、蛋白水解和脂肪分解增加。细胞因子在癌症恶病质的发展中起主要作用：肿瘤坏死因子、白细胞介素1和6、干扰素α和γ。本研究的目的是收集弗罗茨瓦夫医科大学肺病科治疗的肺癌患者恶病质的相关信息。我们观察了76例近期诊断为肺癌的患者（43例男性，33例女性），50例非小细胞肺癌患者和26例小细胞肺癌患者。平均年龄61±9.76岁。我们根据体重减轻的百分比将所有患者分为四组，并对这些组进行比较。我们评估了疾病程度、人体测量和生化参数。在所有患者中，我们发现23例（32%）有恶病质。有恶病质和无恶病质的患者之间仅有一些差异。老年男性体重减轻更明显。
恶病质综合征在肺癌患者诊断时并非重要问题。
