Lu Yan, Chen Ren-Gang, Wei San-Zou, Hu Han-Guo, Sun Fei, Yu Chun-Hui
Department of Clinical Laboratory, The First People's Hospital of Xiaochang, Xiaochang Department of Clinical Laboratory, Xiaogan Central Hospital, Xiaogan County, Hubei, China.
Medicine (Baltimore). 2018 Sep;97(37):e11971. doi: 10.1097/MD.0000000000011971.
This study investigated the anti-inflammatory effects of omega 3 fatty acids (O3FAs) for patients with advanced nonsmall cell lung cancer (ANSCLC).A total of 137 patients with ANSCLC were included in this study. Of those, 77 patients underwent O3FA and were assigned to a treatment group, while 60 patients did not receive it, and were assigned to a control group. C-reactive protein (CRP), and interleukin (IL)-6 levels, as well as the levels of tumor necrosis factor-alpha (TNFα) and prostaglandin E2 (PGE2) were checked. In addition, nutritional status and quality of life were also evaluated. All patients in the treatment group received a total of 6 weeks treatment.After 6 weeks treatment, patients in the treatment group exerted better outcomes in CRP and IL-6, although no significant differences were found in nutritional status, as well as the quality, compared with patients in the control group.The results of this retrospective study found that O3FA may change levels of CRP and IL-6, except the nutritional status and quality of life.
本研究调查了ω-3脂肪酸（O3FAs）对晚期非小细胞肺癌（ANSCLC）患者的抗炎作用。本研究共纳入137例晚期非小细胞肺癌患者。其中，77例患者接受了O3FA治疗并被分配到治疗组，而60例患者未接受该治疗，被分配到对照组。检测了C反应蛋白（CRP）、白细胞介素（IL）-6水平，以及肿瘤坏死因子-α（TNFα）和前列腺素E2（PGE2）水平。此外，还评估了营养状况和生活质量。治疗组所有患者共接受6周治疗。治疗6周后，治疗组患者在CRP和IL-6方面取得了更好的结果，尽管与对照组患者相比，在营养状况和生活质量方面未发现显著差异。这项回顾性研究的结果发现，O3FA可能会改变CRP和IL-6水平，但不会影响营养状况和生活质量。
