Flerov M A, Gerasimova I A, Rakitskaya V V
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St. Petersburg, Russia.
Neurosci Behav Physiol. 2003 Nov;33(9):889-91. doi: 10.1023/a:1025948805807.
Lipid peroxidation processes were studied in the striatum during stress in conditions of prior administration of cortisol. Three doses of cortisol (25 mg/kg, daily) had no significant effect on the levels of lipid peroxidation products six days after injections ended. However, lipid peroxidation responses to stress during this period in animals given cortisol were significantly stronger than in controls (there were decreases in the intermediate products of lipid peroxidation and increases in the quantities of Schiff bases). Thus, administration of hormone leads to long-term changes in one of the most important regulatory systems of the body--lipid peroxidation--and has sensitizing effects on changes in the levels of stress-induced lipid peroxidation products.
在预先给予皮质醇的条件下，研究了应激期间纹状体中的脂质过氧化过程。注射结束六天后，三种剂量的皮质醇（每日25毫克/千克）对脂质过氧化产物水平没有显著影响。然而，在此期间，给予皮质醇的动物对应激的脂质过氧化反应明显强于对照组（脂质过氧化中间产物减少，席夫碱数量增加）。因此，激素给药会导致身体最重要的调节系统之一——脂质过氧化——发生长期变化，并对应激诱导的脂质过氧化产物水平变化产生敏感化作用。
